What is Radial Neuropathy


Radial Nerve


– Most frequently at the Spiral Groove of the humerus
– Could be at the Axilla (Saturday Night palsy)
– Or in the Forearm (Posterior Interosseous Syndrome)


– Wrist drop, Patient unable to extend wrist or fingers up
– Almost always unilateral
– No associated pain
– Occasional forearm/hand/thumb numbness
– Symptoms always present no night/day preference


– Sudden
– Usually happens upon waking up one morning
– Or, after a “Saturday Night” at the bar falling asleep with arm hanging over back of chair
– Or following prolonged sitting in a position with arm leaning against sharp object
– Or following misplaced intramuscular injection in the vicinity of the Radial nerve


– No gender preference
– Diabetes or family history of Diabetes, Alcoholism
– Leaning on arms/axilla, sleeping in wrong position or with somebody leaning on arm, trauma


– When first seen, weakness but no atrophy – Wrist drop with inability to extend wrist, fingers
– Always check the three following muscles:
– Triceps: Ask subject to extend elbow
– Brachio-Radialis: Ask subject, with thumb pointing to ceiling, to flex forearm. Make sure the belly of the Brachio-Radialis is easily visible (compare to healthy side)
– Extensor Indicis Proprius: With hand flat on bed, ask subject to raise index finger up
– Occasional numbness/decreased sensation over dorsum of hand/thumb area
– Difficulty spreading fingers (pseudo-ulnar interosseii weakness)
– Pseudo-Ulnar weakness correctible when wrist held level with forearm by examiner
– Positive Tinel sign (tingling upon tapping nerve) at the humeral Spiral Groove when lesion at that location


Three possible locations determined by exam of Triceps, Brachio-Radialis and Extensor Indicis Proprius

Axilla: Triceps, Brachio-Radialis and Extensor Indicis Proprius all weak, normal to decreased sensation over dorsum hand/thumb area

Humeral Spiral Groove: Triceps strength is normal, weak Brachio-Radialis (can barely see belly of muscle) and weak Extensor Indicis Proprius, normal to decreased sensation over dorsum hand/thumb area

Forearm (Posterior Interosseous Syndrome): Triceps and Brachio-Radialis normal, Extensor Indicis Proprius weak, normal sensation over dorsum hand/thumb area


– Very Good for localization (Axilla, Spiral Groove, Forearm)
– Very Good for Prognostic value: In pure myelin lesions (conduction block), recovery may occur after three weeks to a month
   – In moderate/severe axonal lesions, recovery may take from 6 months to a year
   – In mixed lesions, somewhere in between

   – Slowing, drop in Extensor Indicis Proprius amplitude across compression area in myelin lesions
   – Diffuse drop in Extensor Indicis Proprius amplitude with or without slowing in axonal lesions
   – Mixture of above in mixed lesions
   – Radial sensory spared only in forearm (posterior interosseous) lesions


– Symptomatic treatment
– Stop/decrease cause
– Wrist/finger splint to keep fingers extended in moderate to severe axonal lesions
– Passive wrist, fingers Range of Motion to maintain mobility


– If other nerves involved, could be Brachial Plexus lesion (do not make the mistake of diagnosing a superimposed Ulnar neuropathy because the interosseii “appear” weak)
– Bilateral Radial palsies, always look for Lead poisoning
– Very rarely, Myotonic Dystrophy can cause weak, wasted forearms and bilateral wrist drop